Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8854
Gene Symbol: ALDH1A2
ALDH1A2 		0.120 GeneticVariation disease GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790 2013
Entrez Id: 23373
Gene Symbol: CRTC1
CRTC1 		0.110 GeneticVariation disease GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790 2013
Entrez Id: 81696
Gene Symbol: OR5V1
OR5V1 		0.100 GeneticVariation disease GWASDB Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. 22961001 2012
Entrez Id: 81797
Gene Symbol: OR12D3
OR12D3 		0.100 GeneticVariation disease GWASDB Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. 22961001 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker disease RGD [Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide]. 17675820 2007
Entrez Id: 652
Gene Symbol: BMP4
BMP4 		0.240 Biomarker disease RGD Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. 17570215 2007
Entrez Id: 9536
Gene Symbol: PTGES
PTGES 		0.230 Biomarker disease RGD In the case of Barrett's oesophagus, COX-2 and mPGES-1 were predominantly in subepithelial stromal cells. mRNA levels of COX-2, mPGES-1, EP2, EP3, and EP4 were higher in the experimental groups than in controls. 14684572 2004
Entrez Id: 8678
Gene Symbol: BECN1
BECN1 		0.210 Biomarker disease RGD The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid. 22301112 2012
Entrez Id: 115908
Gene Symbol: CTHRC1
CTHRC1 		0.410 Biomarker disease HPO
Entrez Id: 4481
Gene Symbol: MSR1
MSR1 		0.410 Biomarker disease HPO
Entrez Id: 51008
Gene Symbol: ASCC1
ASCC1 		0.410 Biomarker disease HPO
Entrez Id: 2271
Gene Symbol: FH
FH 		0.100 Biomarker disease HPO
Entrez Id: 5885
Gene Symbol: RAD21
RAD21 		0.100 Biomarker disease HPO
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression disease LHGDN Acid exposure has been shown both to activate the MAPK pathways and to increase COX-2 protein expression in Barrett's metaplasia, but it is not known whether these effects are interrelated. 15231484 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker disease LHGDN COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, thereby leading to carcinogenesis. 16521222 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.100 Biomarker disease LHGDN Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. 16521222 2006
Entrez Id: 1045
Gene Symbol: CDX2
CDX2 		0.100 Biomarker disease LHGDN Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. 14576477 2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.100 PosttranslationalModification disease LHGDN Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk. 15824739 2005
Entrez Id: 1045
Gene Symbol: CDX2
CDX2 		0.100 Biomarker disease LHGDN Accordingly, Cdx2 immunostaining could help identify patients with Barrett's metaplasia in cases where no goblet cells are visible in biopsies from the columnar-lined esophagus. 15167938 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		0.100 GeneticVariation disease LHGDN p16 mutation spectrum in the premalignant condition Barrett's esophagus. 19043591 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease LHGDN p53 in esophageal adenocarcinoma: a critical reassessment of mutation frequency and identification of 72Arg as the dominant allele. 17982662 2007
Entrez Id: 324
Gene Symbol: APC
APC 		0.100 PosttranslationalModification disease LHGDN Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus. 16407829 2006
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.070 AlteredExpression disease LHGDN Increased expression and secretion of interleukin-6 in patients with Barrett's esophagus. 15041721 2004
Entrez Id: 1044
Gene Symbol: CDX1
CDX1 		0.070 Biomarker disease LHGDN Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus. 18953412 2008
Entrez Id: 4609
Gene Symbol: MYC
MYC 		0.060 Biomarker disease LHGDN Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus. 18953412 2008